{"entity":{"id":"stx-001","kind":"drug","name":"STX-001","aka":[],"tldr":"STX-001 is an experimental self-replicating mRNA in lipid nanoparticle from Strand Therapeutics, in phase 1 trials for melanoma, advanced solid tumours and triple-negative breast cancer and other cancers.","summary":"STX-001 is a self-replicating mRNA in lipid nanoparticle (intratumoural) from Strand Therapeutics. A lipid nanoparticle-encapsulated self-replicating mRNA that makes tumour cells express interleukin-12, injected into tumours. Its furthest stage is phase 1, for melanoma, advanced solid tumours, triple-negative breast cancer and head and neck cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 recruiting since May 2024 (registry), alone and with pembrolizumab. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Strand Therapeutics: strandtx.com","url":"https://www.strandtx.com/pipeline"},{"label":"Strand Therapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT06249048"},{"label":"ClinicalTrials.gov: trials of STX-001","url":"https://clinicaltrials.gov/search?intr=STX-001"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["strand-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06249048"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"STX-001","modality":"Self-replicating mRNA in lipid nanoparticle (intratumoural)","mechanism":"A lipid nanoparticle-encapsulated self-replicating mRNA that makes tumour cells express interleukin-12, injected into tumours.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/stx-001/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"strand-therapeutics","kind":"company","name":"Strand Therapeutics","route":"/companies/strand-therapeutics/"}],"trial":[{"id":"nct06249048","kind":"trial","name":"Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab","route":"/trials/nct06249048/"}]}}