{"entity":{"id":"stx-003","kind":"drug","name":"STX-003","aka":[],"tldr":"STX-003 is an experimental self-replicating mRNA circuit in lipid nanoparticle from Strand Therapeutics, in phase 1 trials for non-small cell lung cancer and advanced solid tumours.","summary":"STX-003 is a self-replicating mRNA circuit in lipid nanoparticle (intravenous) from Strand Therapeutics. A systemically delivered self-replicating mRNA encoding IL-12 with microRNA target sites, so that it is expressed in tumour cells and switched off elsewhere. Its furthest stage is phase 1, for non-small cell lung cancer and advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 recruiting, started 2026-06-30 (registry), alone and with pembrolizumab. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Strand Therapeutics: strandtx.com","url":"https://www.strandtx.com/pipeline"},{"label":"Strand Therapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07751042"},{"label":"ClinicalTrials.gov: trials of STX-003","url":"https://clinicaltrials.gov/search?intr=STX-003"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["strand-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07751042"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"STX-003","modality":"Self-replicating mRNA circuit in lipid nanoparticle (intravenous)","mechanism":"A systemically delivered self-replicating mRNA encoding IL-12 with microRNA target sites, so that it is expressed in tumour cells and switched off elsewhere.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/stx-003/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"strand-therapeutics","kind":"company","name":"Strand Therapeutics","route":"/companies/strand-therapeutics/"}],"trial":[{"id":"nct07751042","kind":"trial","name":"Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab","route":"/trials/nct07751042/"}]}}