{"entity":{"id":"stx-005","kind":"drug","name":"STX-005","aka":[],"tldr":"STX-005 is an experimental circular mRNA circuit for in vivo CAR-T from Strand Therapeutics, in preclinical development for haematological malignancies.","summary":"STX-005 is a circular mRNA circuit for in vivo CAR-T (systemic) from Strand Therapeutics. A systemically delivered circular mRNA circuit designed to generate CAR-T cells inside the body. Its furthest stage is preclinical development, for haematological malignancies. No clinical trial naming it is registered on ClinicalTrials.gov. No registry entry; the company's site links an April 2026 press release on preclinical in vivo CAR-T data at ASGCT 2026 (BusinessWire blocked the fetch, so only the headline/URL was seen). It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Strand Therapeutics: strandtx.com","url":"https://www.strandtx.com/pipeline"},{"label":"Strand Therapeutics: strandtx.com","url":"https://www.strandtx.com/pipeline"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["strand-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"STX-005","modality":"Circular mRNA circuit for in vivo CAR-T (systemic)","mechanism":"A systemically delivered circular mRNA circuit designed to generate CAR-T cells inside the body.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/stx-005/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"strand-therapeutics","kind":"company","name":"Strand Therapeutics","route":"/companies/strand-therapeutics/"}]}}