{"entity":{"id":"surufatinib","kind":"drug","name":"Surufatinib","aka":["sulfatinib","Sulanda"],"tldr":"Surufatinib is HUTCHMED's angio-immuno kinase inhibitor, approved in China in 2020 for non-pancreatic and in 2021 for pancreatic neuroendocrine tumours.","summary":"Surufatinib (Sulanda) was discovered and developed by HUTCHMED in Shanghai. The NMPA approved it in December 2020 for unresectable locally advanced or metastatic, well-differentiated, non-pancreatic neuroendocrine tumours (SANET-ep trial) and in June 2021 for pancreatic neuroendocrine tumours (SANET-p trial). A US application was withdrawn in 2022 after the FDA asked for a multi-regional trial.","status":"approved","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of surufatinib","url":"https://clinicaltrials.gov/search?intr=surufatinib"}],"tags":["china","nmpa-approved"],"related":[],"cancers":["neuroendocrine"],"sections":[],"technologies":["kinase-inhibitors"],"targets":["vegf","csf1r"],"drugs":[],"companies":["hutchmed"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo China deep dive","editedOn":"2026-09-16"},"code":"HMPL-012","modality":"Oral VEGFR, FGFR1 and CSF1R tyrosine kinase inhibitor","mechanism":"Blocks the VEGF and FGF receptors that build tumour blood vessels and the CSF1 receptor on tumour-associated macrophages, cutting the tumour's blood supply and its immune shelter at once.","approvals":[{"region":"CN","year":2020,"indication":"Advanced non-pancreatic neuroendocrine tumours; pancreatic neuroendocrine tumours from 2021"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/surufatinib/","neighbours":{"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"target":[{"id":"csf1r","kind":"target","name":"CSF1R","route":"/targets/csf1r/"},{"id":"vegf","kind":"target","name":"VEGF / VEGFR","route":"/targets/vegf/"}],"company":[{"id":"hutchmed","kind":"company","name":"Hutchmed","route":"/companies/hutchmed/"}]}}