{"entity":{"id":"susd2","kind":"target","name":"SUSD2","aka":["sushi domain containing 2","Sushi domain-containing protein 2","BK65A6.2","FLJ22778","W5C5"],"tldr":"SUSD2 (Sushi domain-containing protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30667"},{"label":"UniProt Q9UGT4","url":"https://www.uniprot.org/uniprotkb/Q9UGT4/entry"},{"label":"NCBI Gene 56241","url":"https://www.ncbi.nlm.nih.gov/gene/56241"},{"label":"Ensembl ENSG00000099994","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000099994"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SUSD2","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30667","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UGT4","url":"https://www.uniprot.org/uniprotkb/Q9UGT4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SUSD2","url":"https://www.intogen.org/search?gene=SUSD2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30667","ensembl":"ENSG00000099994","uniprot":"Q9UGT4","entrez":"56241","biology":"May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis. Location: Cell membrane (UniProt). Locus 22q11.23 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/susd2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}