{"entity":{"id":"suz12","kind":"target","name":"SUZ12","aka":["SUZ12 polycomb repressive complex 2 subunit","Polycomb protein SUZ12","JJAZ1","KIAA0160","CHET9"],"tldr":"SUZ12 (Polycomb protein SUZ12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Breast cancer, Prostate cancer and 4 more.","summary":"Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems.\n\nOpen Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes affected pathway 0.72, literature 0.94, genetic association 0.02, somatic mutation 0.89, animal model 0.54). IntOGen calls it a driver in 4 cohorts (2 activating, 2 loss-of-function), covering Acute Myeloid Leukaemia, Prostate Adenocarcinoma, Sarcoma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17101","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17101"},{"label":"UniProt Q15022","url":"https://www.uniprot.org/uniprotkb/Q15022/entry"},{"label":"NCBI Gene 23512","url":"https://www.ncbi.nlm.nih.gov/gene/23512"},{"label":"Ensembl ENSG00000178691","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178691"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","breast-cancer","prostate","sarcoma","non-hodgkin-lymphoma","skin-cancer","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SUZ12","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:17101","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17101","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15022","url":"https://www.uniprot.org/uniprotkb/Q15022/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000178691","url":"https://platform.opentargets.org/target/ENSG00000178691/associations","note":"association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: prostate cancer 0.51, sarcoma 0.53, non-Hodgkin lymphoma 0.52, skin cancer 0.52, breast cancer 0.61, leukaemia 0.61 (GraphQL API, CC0)"},{"label":"IntOGen SUZ12","url":"https://www.intogen.org/search?gene=SUZ12","note":"driver in 4 cohorts (Act 2, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:17101","ensembl":"ENSG00000178691","uniprot":"Q15022","entrez":"23512","biology":"Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)","Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315); IntOGen driver in 2 cohorts (PRAD)","Sarcomas: Open Targets association 0.53 with sarcoma (MONDO_0005089); IntOGen driver in 1 cohort (SARCNOS)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/suz12/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}