{"entity":{"id":"syk","kind":"target","name":"SYK","aka":["spleen associated tyrosine kinase","Tyrosine-protein kinase SYK"],"tldr":"SYK (Tyrosine-protein kinase SYK) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer, Skin cancer, Lung cancer and 4 more.","summary":"Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signalling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.50, literature 0.99, genetic association 0.38, somatic mutation 0.98, animal model 0.51). In OnCo, 1 product record names it (Fostamatinib).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11491","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11491"},{"label":"UniProt P43405","url":"https://www.uniprot.org/uniprotkb/P43405/entry"},{"label":"NCBI Gene 6850","url":"https://www.ncbi.nlm.nih.gov/gene/6850"},{"label":"Ensembl ENSG00000165025","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165025"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["ovarian","skin-cancer","lung-cancer","breast-cancer","colorectal","leukaemia","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["fostamatinib"],"companies":[],"institutions":[],"pathways":["bcr-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.50; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SYK","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11491","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11491","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P43405","url":"https://www.uniprot.org/uniprotkb/P43405/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SYK","url":"https://civicdb.org/features/5572","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000165025","url":"https://platform.opentargets.org/target/ENSG00000165025/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.54, melanoma 0.56, skin cancer 0.58, breast cancer 0.54, lung cancer 0.55, leukaemia 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:11491","ensembl":"ENSG00000165025","uniprot":"P43405","entrez":"6850","biology":"Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signalling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Location: Cell membrane; Cytoplasm, cytosol (UniProt). Locus 9q22.2 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease","Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)","Leukaemia: Open Targets association 0.50 with leukaemia (MONDO_0005059)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/syk/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"drug":[{"id":"fostamatinib","kind":"drug","name":"Fostamatinib","route":"/drugs/fostamatinib/"}],"pathway":[{"id":"bcr-signalling","kind":"pathway","name":"B-cell receptor / BTK signalling (to NF-κB)","route":"/pathways/bcr-signalling/"}]}}