{"entity":{"id":"taf15","kind":"target","name":"TAF15","aka":["TATA-box binding protein associated factor 15","TATA-binding protein-associated factor 2N","hTAFII68","RBP56","Npl3","TAF2N"],"tldr":"TAF15 (TATA-binding protein-associated factor 2N) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Mesothelioma and Pleural mesothelioma.","summary":"RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11547","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11547"},{"label":"UniProt Q92804","url":"https://www.uniprot.org/uniprotkb/Q92804/entry"},{"label":"NCBI Gene 8148","url":"https://www.ncbi.nlm.nih.gov/gene/8148"},{"label":"Ensembl ENSG00000270647","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000270647"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","mesothelioma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TAF15","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11547","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11547","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92804","url":"https://www.uniprot.org/uniprotkb/Q92804/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TAF15","url":"https://www.intogen.org/search?gene=TAF15","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11547","ensembl":"ENSG00000270647","uniprot":"Q92804","entrez":"8148","biology":"RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Location: Nucleus; Cytoplasm (UniProt). Locus 17q12 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/taf15/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}