{"entity":{"id":"taf1l","kind":"target","name":"TAF1L","aka":["TATA-box binding protein associated factor 1 like","Transcription initiation factor TFIID subunit 1-like"],"tldr":"TAF1L (Transcription initiation factor TFIID subunit 1-like) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18056","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18056"},{"label":"UniProt Q8IZX4","url":"https://www.uniprot.org/uniprotkb/Q8IZX4/entry"},{"label":"NCBI Gene 138474","url":"https://www.ncbi.nlm.nih.gov/gene/138474"},{"label":"Ensembl ENSG00000122728","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122728"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TAF1L","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18056","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18056","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IZX4","url":"https://www.uniprot.org/uniprotkb/Q8IZX4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TAF1L","url":"https://www.intogen.org/search?gene=TAF1L","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18056","ensembl":"ENSG00000122728","uniprot":"Q8IZX4","entrez":"138474","biology":"May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Location: Nucleus (UniProt). Locus 9p21.1 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/taf1l/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}