{"entity":{"id":"tal1","kind":"target","name":"TAL1","aka":["TAL bHLH transcription factor 1, erythroid differentiation factor","T-cell acute lymphocytic leukemia protein 1","bHLHa17","TCL5"],"tldr":"TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.","summary":"Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.64, somatic mutation 0.75). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11556","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11556"},{"label":"UniProt P17542","url":"https://www.uniprot.org/uniprotkb/P17542/entry"},{"label":"NCBI Gene 6886","url":"https://www.ncbi.nlm.nih.gov/gene/6886"},{"label":"Ensembl ENSG00000162367","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162367"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","non-hodgkin-lymphoma","skin-cancer","leukaemia","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TAL1","role":["fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11556","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11556","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P17542","url":"https://www.uniprot.org/uniprotkb/P17542/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000162367","url":"https://platform.opentargets.org/target/ENSG00000162367/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.52, non-Hodgkin lymphoma 0.56, skin cancer 0.52, leukaemia 0.52 (GraphQL API, CC0)"},{"label":"IntOGen TAL1","url":"https://www.intogen.org/search?gene=TAL1","note":"driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11556","ensembl":"ENSG00000162367","uniprot":"P17542","entrez":"6886","biology":"Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. Location: Nucleus (UniProt). Locus 1p33 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Acute lymphoblastic leukaemia: Open Targets association 0.52 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tal1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}