{"entity":{"id":"tal2","kind":"target","name":"TAL2","aka":["TAL bHLH transcription factor 2","T-cell acute lymphocytic leukemia protein 2","bHLHa19"],"tldr":"TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"UniProt has no function text for Q16559; HGNC names it \"TAL bHLH transcription factor 2\".\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.09, animal model 0.50, genetic association 0.07, somatic mutation 0.80). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11557"},{"label":"UniProt Q16559","url":"https://www.uniprot.org/uniprotkb/Q16559/entry"},{"label":"NCBI Gene 6887","url":"https://www.ncbi.nlm.nih.gov/gene/6887"},{"label":"Ensembl ENSG00000186051","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186051"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TAL2","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11557","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16559","url":"https://www.uniprot.org/uniprotkb/Q16559/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000186051","url":"https://platform.opentargets.org/target/ENSG00000186051/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"},{"label":"IntOGen TAL2","url":"https://www.intogen.org/search?gene=TAL2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11557","ensembl":"ENSG00000186051","uniprot":"Q16559","entrez":"6887","biology":"UniProt has no function text for Q16559; HGNC names it \"TAL bHLH transcription factor 2\". Locus 9q31.2 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/tal2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}