{"entity":{"id":"targeted-panel-sequencing","kind":"term","name":"Targeted panel sequencing","aka":["targeted panel sequencing","targeted-panel sequencing","gene panel sequencing","targeted gene panel","clinical sequencing panel","hundreds of genes panel"],"tldr":"A targeted panel sequences only a chosen set of a few hundred cancer genes, deeply and cheaply, which is what most hospitals run on tumours today.","summary":"Exome sequencing works by selecting a subset of DNA before sequencing (Wikipedia); a targeted panel narrows the selection further to hundreds of clinically relevant genes, read at high depth from small samples. Panels such as MSK-IMPACT and FoundationOne underlie AACR Project GENIE, the largest clinico-genomic dataset, but panel coverage differs between institutions, so pooling requires restricting to shared genes and treating unsequenced genes as missing rather than wild type.","asOf":"2026-09-24","wikipedia":"https://en.wikipedia.org/wiki/Exome_sequencing","links":[{"label":"AACR Project GENIE","url":"https://www.aacr.org/professionals/research/aacr-project-genie/"},{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Exome_sequencing"}],"tags":["cansim-terms"],"related":["genie","cancer-ai-vocabulary"],"cancers":[],"sections":[],"technologies":["cgp"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["somatic-mutations-wxs-wgs","cancer-drivers-vs-actionable"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/targeted-panel-sequencing."],"provenance":{"editedBy":"OnCo CanSim terms wave (Wikipedia summaries, standards and project pages, GDC and FDA pages, Europe PMC)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"category":"Diagnostics & imaging"},"route":"/terms/targeted-panel-sequencing/","neighbours":{"collection":[{"id":"genie","kind":"collection","name":"AACR Project GENIE","route":"/collections/genie/"}],"term":[{"id":"cancer-drivers-vs-actionable","kind":"term","name":"Actionable genomic biomarkers","route":"/terms/cancer-drivers-vs-actionable/"},{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"somatic-mutations-wxs-wgs","kind":"term","name":"Somatic mutations from exome and genome sequencing (WXS, WGS)","route":"/terms/somatic-mutations-wxs-wgs/"}],"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"}]}}