{"entity":{"id":"tbk1","kind":"target","name":"TBK1","aka":["TANK binding kinase 1","Serine/threonine-protein kinase TBK1"],"tldr":"TBK1 (Serine/threonine-protein kinase TBK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerisation and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Selumetinib and AZ909. In OnCo, 1 product record names it (ADU-S100 (MIW815)).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11584","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11584"},{"label":"UniProt Q9UHD2","url":"https://www.uniprot.org/uniprotkb/Q9UHD2/entry"},{"label":"NCBI Gene 29110","url":"https://www.ncbi.nlm.nih.gov/gene/29110"},{"label":"Ensembl ENSG00000183735","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183735"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["adu-s100"],"companies":[],"institutions":[],"pathways":["cgas-sting"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TBK1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11584","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11584","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UHD2","url":"https://www.uniprot.org/uniprotkb/Q9UHD2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TBK1","url":"https://civicdb.org/features/11322","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"hgnc":"HGNC:11584","ensembl":"ENSG00000183735","uniprot":"Q9UHD2","entrez":"29110","biology":"Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerisation and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1. Phosphorylated IRF3 dissociates from the adapter proteins, dimerises, and then enters the nucleus to induce expression of interferons. Location: Cytoplasm (UniProt). Locus 12q14.2 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/tbk1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"drug":[{"id":"adu-s100","kind":"drug","name":"ADU-S100 (MIW815)","route":"/drugs/adu-s100/"}],"pathway":[{"id":"cgas-sting","kind":"pathway","name":"cGAS-STING innate sensing","route":"/pathways/cgas-sting/"}]}}