{"entity":{"id":"tbl1xr1","kind":"target","name":"TBL1XR1","aka":["TBL1X/Y related 1","F-box-like/WD repeat-containing protein TBL1XR1","IRA1","FLJ12894","TBLR1","C21","DC42"],"tldr":"TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.","summary":"F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.96, animal model 0.28, genetic association 0.34, somatic mutation 0.83). IntOGen calls it a driver in 9 cohorts (8 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Burkitt Lymphoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29529","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29529"},{"label":"UniProt Q9BZK7","url":"https://www.uniprot.org/uniprotkb/Q9BZK7/entry"},{"label":"NCBI Gene 79718","url":"https://www.ncbi.nlm.nih.gov/gene/79718"},{"label":"Ensembl ENSG00000177565","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177565"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","leukaemia","breast-cancer","mesothelioma","lung-cancer","skin-cancer","dlbcl","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 8 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TBL1XR1","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:29529","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29529","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BZK7","url":"https://www.uniprot.org/uniprotkb/Q9BZK7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TBL1XR1","url":"https://civicdb.org/features/15004","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000177565","url":"https://platform.opentargets.org/target/ENSG00000177565/associations","note":"association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: melanoma 0.51, diffuse large B-cell lymphoma 0.67, non-Hodgkin lymphoma 0.74, skin cancer 0.52, breast cancer 0.58, lung cancer 0.52 (GraphQL API, CC0)"},{"label":"IntOGen TBL1XR1","url":"https://www.intogen.org/search?gene=TBL1XR1","note":"driver in 9 cohorts (Act 8, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29529","ensembl":"ENSG00000177565","uniprot":"Q9BZK7","entrez":"79718","biology":"F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Location: Nucleus (UniProt). Locus 3q26.32 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.74 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (MLYM, NHL)","Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tbl1xr1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}