{"entity":{"id":"tbpl1","kind":"target","name":"TBPL1","aka":["TATA-box binding protein like 1","TATA box-binding protein-like 1","TRF2"],"tldr":"TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11589","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11589"},{"label":"UniProt P62380","url":"https://www.uniprot.org/uniprotkb/P62380/entry"},{"label":"NCBI Gene 9519","url":"https://www.ncbi.nlm.nih.gov/gene/9519"},{"label":"Ensembl ENSG00000028839","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000028839"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TBPL1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11589","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11589","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62380","url":"https://www.uniprot.org/uniprotkb/P62380/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000028839","url":"https://platform.opentargets.org/target/ENSG00000028839/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11589","ensembl":"ENSG00000028839","uniprot":"P62380","entrez":"9519","biology":"Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. Location: Cytoplasm; Nucleus (UniProt). Locus 6q23.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/tbpl1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}