{"entity":{"id":"tbxt","kind":"target","name":"TBXT","aka":["T-box transcription factor T"],"tldr":"TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.","summary":"Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.\n\nCIViC holds 5 clinical evidence items and 0 assertions across 3 variants, naming Nivolumab. In OnCo, 1 product record names it (GI-6301).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11515"},{"label":"UniProt O15178","url":"https://www.uniprot.org/uniprotkb/O15178/entry"},{"label":"NCBI Gene 6862","url":"https://www.ncbi.nlm.nih.gov/gene/6862"},{"label":"Ensembl ENSG00000164458","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164458"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["chordoma"],"sections":[],"technologies":[],"targets":[],"drugs":["gi-6301"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Poorly Differentiated Chordoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TBXT","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11515","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15178","url":"https://www.uniprot.org/uniprotkb/O15178/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TBXT","url":"https://civicdb.org/features/5581","note":"5 evidence items, 0 assertions, 3 variants; diseases: Chordoma, Poorly Differentiated Chordoma (GraphQL API, CC0)"}],"hgnc":"HGNC:11515","ensembl":"ENSG00000164458","uniprot":"O15178","entrez":"6862","biology":"Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. Location: Nucleus (UniProt). Locus 6q27 (HGNC).","whereFound":["Chordoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tbxt/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"chordoma","kind":"cancer","name":"Chordoma","route":"/cancers/chordoma/"}],"drug":[{"id":"gi-6301","kind":"drug","name":"GI-6301","route":"/drugs/gi-6301/"}]}}