{"entity":{"id":"tcea1","kind":"target","name":"TCEA1","aka":["transcription elongation factor A1","Transcription elongation factor A protein 1","TF2S","TFIIS","GTF2S"],"tldr":"TCEA1 (Transcription elongation factor A protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.","summary":"Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.23, genetic association 0.00, somatic mutation 0.89).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11612","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11612"},{"label":"UniProt P23193","url":"https://www.uniprot.org/uniprotkb/P23193/entry"},{"label":"NCBI Gene 6917","url":"https://www.ncbi.nlm.nih.gov/gene/6917"},{"label":"Ensembl ENSG00000187735","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187735"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCEA1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11612","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11612","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23193","url":"https://www.uniprot.org/uniprotkb/P23193/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000187735","url":"https://platform.opentargets.org/target/ENSG00000187735/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: oral cavity cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:11612","ensembl":"ENSG00000187735","uniprot":"P23193","entrez":"6917","biology":"Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).","whereFound":["Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tcea1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}