{"entity":{"id":"tcf12","kind":"target","name":"TCF12","aka":["transcription factor 12","Transcription factor 12","HTF4","HsT17266","bHLHb20","p64"],"tldr":"TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Low-Grade Glioma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11623"},{"label":"UniProt Q99081","url":"https://www.uniprot.org/uniprotkb/Q99081/entry"},{"label":"NCBI Gene 6938","url":"https://www.ncbi.nlm.nih.gov/gene/6938"},{"label":"Ensembl ENSG00000140262","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140262"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCF12","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11623","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99081","url":"https://www.uniprot.org/uniprotkb/Q99081/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TCF12","url":"https://www.intogen.org/search?gene=TCF12","note":"driver in 2 cohorts (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11623","ensembl":"ENSG00000140262","uniprot":"Q99081","entrez":"6938","biology":"Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). May be involved in the functional network that regulates the development of the GnRH axis. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tcf12/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}