{"entity":{"id":"tcf19","kind":"target","name":"TCF19","aka":["transcription factor 19","Transcription factor 19","SC1"],"tldr":"TCF19 (Transcription factor 19) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mirdametinib and Birabresib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11629","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11629"},{"label":"UniProt Q9Y242","url":"https://www.uniprot.org/uniprotkb/Q9Y242/entry"},{"label":"NCBI Gene 6941","url":"https://www.ncbi.nlm.nih.gov/gene/6941"},{"label":"Ensembl ENSG00000137310","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137310"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCF19","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11629","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11629","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y242","url":"https://www.uniprot.org/uniprotkb/Q9Y242/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TCF19","url":"https://civicdb.org/features/5654","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"hgnc":"HGNC:11629","ensembl":"ENSG00000137310","uniprot":"Q9Y242","entrez":"6941","biology":"Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1. Location: Nucleus (UniProt). Locus 6p21.33 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tcf19/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}