{"entity":{"id":"tcf3","kind":"target","name":"TCF3","aka":["transcription factor 3","Transcription factor E2-alpha","E2A","ITF1","MGC129647","MGC129648","bHLHb21","E47","p75"],"tldr":"TCF3 (Transcription factor E2-alpha) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Non-Hodgkin lymphoma, Lung cancer and 3 more.","summary":"Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11633","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11633"},{"label":"UniProt P15923","url":"https://www.uniprot.org/uniprotkb/P15923/entry"},{"label":"NCBI Gene 6929","url":"https://www.ncbi.nlm.nih.gov/gene/6929"},{"label":"Ensembl ENSG00000071564","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000071564"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","lung-cancer","burkitt-lymphoma","all-leukemia","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCF3","role":["biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11633","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11633","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15923","url":"https://www.uniprot.org/uniprotkb/P15923/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TCF3","url":"https://civicdb.org/features/5646","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000071564","url":"https://platform.opentargets.org/target/ENSG00000071564/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.51, acute lymphoblastic leukaemia 0.58, non-Hodgkin lymphoma 0.61, lung cancer 0.53, leukaemia 0.61 (GraphQL API, CC0)"}],"hgnc":"HGNC:11633","ensembl":"ENSG00000071564","uniprot":"P15923","entrez":"6929","biology":"Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. Location: Nucleus (UniProt). Locus 19p13.3 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Burkitt lymphoma: CIViC evidence names this disease","Acute lymphoblastic leukaemia: Open Targets association 0.58 with acute lymphoblastic leukaemia (MONDO_0004967)","Non-small-cell lung cancer: Open Targets association 0.51 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tcf3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}