{"entity":{"id":"tcf4","kind":"target","name":"TCF4","aka":["transcription factor 4","Transcription factor 4","SEF2-1B","ITF2","bHLHb19","E2-2"],"tldr":"TCF4 (Transcription factor 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.","summary":"Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11634","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11634"},{"label":"UniProt P15884","url":"https://www.uniprot.org/uniprotkb/P15884/entry"},{"label":"NCBI Gene 6925","url":"https://www.ncbi.nlm.nih.gov/gene/6925"},{"label":"Ensembl ENSG00000196628","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196628"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma","paediatric-low-grade-glioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCF4","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11634","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11634","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15884","url":"https://www.uniprot.org/uniprotkb/P15884/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TCF4","url":"https://www.intogen.org/search?gene=TCF4","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11634","ensembl":"ENSG00000196628","uniprot":"P15884","entrez":"6925","biology":"Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Location: Nucleus (UniProt). Locus 18q21.2 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)","Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tcf4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"}]}}