{"entity":{"id":"tcl1a","kind":"target","name":"TCL1A","aka":["TCL1 family AKT coactivator A","T-cell leukemia/lymphoma protein 1A","TCL1"],"tldr":"TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.","summary":"Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.76, genetic association 0.48, somatic mutation 0.89). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11648","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11648"},{"label":"UniProt P56279","url":"https://www.uniprot.org/uniprotkb/P56279/entry"},{"label":"NCBI Gene 8115","url":"https://www.ncbi.nlm.nih.gov/gene/8115"},{"label":"Ensembl ENSG00000100721","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100721"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","skin-cancer","dlbcl","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TCL1A","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11648","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11648","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P56279","url":"https://www.uniprot.org/uniprotkb/P56279/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100721","url":"https://platform.opentargets.org/target/ENSG00000100721/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen TCL1A","url":"https://www.intogen.org/search?gene=TCL1A","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11648","ensembl":"ENSG00000100721","uniprot":"P56279","entrez":"8115","biology":"Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival. Location: Cytoplasm; Nucleus; Microsome; Endoplasmic reticulum (UniProt). Locus 14q32.13 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tcl1a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}