{"entity":{"id":"tent5c","kind":"target","name":"TENT5C","aka":["terminal nucleotidyltransferase 5C","Terminal nucleotidyltransferase 5C","FLJ20202","FAM46C"],"tldr":"TENT5C (Terminal nucleotidyltransferase 5C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma, Skin cancer, Colorectal cancer and 1 more.","summary":"Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.92, animal model 0.44, genetic association 0.10, somatic mutation 0.92). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24712","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24712"},{"label":"UniProt Q5VWP2","url":"https://www.uniprot.org/uniprotkb/Q5VWP2/entry"},{"label":"NCBI Gene 54855","url":"https://www.ncbi.nlm.nih.gov/gene/54855"},{"label":"Ensembl ENSG00000183508","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183508"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["multiple-myeloma","skin-cancer","colorectal","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TENT5C","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:24712","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24712","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5VWP2","url":"https://www.uniprot.org/uniprotkb/Q5VWP2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000183508","url":"https://platform.opentargets.org/target/ENSG00000183508/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.51, plasma cell myeloma 0.54, skin cancer 0.52, lung cancer 0.50 (GraphQL API, CC0)"},{"label":"IntOGen TENT5C","url":"https://www.intogen.org/search?gene=TENT5C","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:24712","ensembl":"ENSG00000183508","uniprot":"Q5VWP2","entrez":"54855","biology":"Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein. Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 1p12 (HGNC).","whereFound":["Multiple myeloma: Open Targets association 0.54 with plasma cell myeloma (MONDO_0009693); IntOGen driver in 3 cohorts (PCM)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tent5c/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}