{"entity":{"id":"tf","kind":"target","name":"TF","aka":["transferrin","Serotransferrin","PRO1557","PRO2086"],"tldr":"TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11740","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11740"},{"label":"UniProt P02787","url":"https://www.uniprot.org/uniprotkb/P02787/entry"},{"label":"NCBI Gene 7018","url":"https://www.ncbi.nlm.nih.gov/gene/7018"},{"label":"Ensembl ENSG00000091513","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091513"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TF","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11740","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11740","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P02787","url":"https://www.uniprot.org/uniprotkb/P02787/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TF","url":"https://civicdb.org/features/5723","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"hgnc":"HGNC:11740","ensembl":"ENSG00000091513","uniprot":"P02787","entrez":"7018","biology":"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation. Location: Secreted (UniProt). Locus 3q22.1 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tf/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}