{"entity":{"id":"tfg","kind":"target","name":"TFG","aka":["trafficking from ER to golgi regulator","TF6","FLJ36137","SPG57"],"tldr":"TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.","summary":"Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.08, somatic mutation 0.79). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11758","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11758"},{"label":"UniProt Q92734","url":"https://www.uniprot.org/uniprotkb/Q92734/entry"},{"label":"NCBI Gene 10342","url":"https://www.ncbi.nlm.nih.gov/gene/10342"},{"label":"Ensembl ENSG00000114354","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114354"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TFG","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11758","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11758","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92734","url":"https://www.uniprot.org/uniprotkb/Q92734/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000114354","url":"https://platform.opentargets.org/target/ENSG00000114354/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen TFG","url":"https://www.intogen.org/search?gene=TFG","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11758","ensembl":"ENSG00000114354","uniprot":"Q92734","entrez":"10342","biology":"Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Location: Endoplasmic reticulum (UniProt). Locus 3q12.2 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/tfg/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}