{"entity":{"id":"tfrc","kind":"target","name":"TFRC","aka":["transferrin receptor","Transferrin receptor protein 1","CD71","TFR1","p90"],"tldr":"TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.","summary":"Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.\n\nIntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Non-Small Cell Lung Cancer, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11763","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11763"},{"label":"UniProt P02786","url":"https://www.uniprot.org/uniprotkb/P02786/entry"},{"label":"NCBI Gene 7037","url":"https://www.ncbi.nlm.nih.gov/gene/7037"},{"label":"Ensembl ENSG00000072274","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072274"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TFRC","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11763","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11763","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P02786","url":"https://www.uniprot.org/uniprotkb/P02786/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TFRC","url":"https://www.intogen.org/search?gene=TFRC","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11763","ensembl":"ENSG00000072274","uniprot":"P02786","entrez":"7037","biology":"Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary haemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Location: Cell membrane; Melanosome; Secreted (UniProt). Locus 3q29 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tfrc/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}