{"entity":{"id":"tg","kind":"target","name":"TG","aka":["thyroglobulin","Thyroglobulin","AITD3"],"tldr":"TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.","summary":"Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.95, animal model 0.59, genetic association 0.72, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11764","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11764"},{"label":"UniProt P01266","url":"https://www.uniprot.org/uniprotkb/P01266/entry"},{"label":"NCBI Gene 7038","url":"https://www.ncbi.nlm.nih.gov/gene/7038"},{"label":"Ensembl ENSG00000042832","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000042832"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TG","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11764","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11764","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P01266","url":"https://www.uniprot.org/uniprotkb/P01266/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000042832","url":"https://platform.opentargets.org/target/ENSG00000042832/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: thyroid cancer 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:11764","ensembl":"ENSG00000042832","uniprot":"P01266","entrez":"7038","biology":"Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Location: Secreted (UniProt). Locus 8q24.22 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.55 with thyroid cancer (MONDO_0002108)"],"targetClass":"other","prevalence":[]},"route":"/targets/tg/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}