{"entity":{"id":"tg6050","kind":"drug","name":"TG6050","aka":[],"tldr":"TG6050 is an experimental oncolytic virus, intravenous from Transgene, in phase 1 trials for metastatic non-small cell lung cancer; its current status is not stated.","summary":"TG6050 is an oncolytic virus (vaccinia, Invir.IO platform), intravenous from Transgene. An oncolytic virus engineered to make human IL-12 and a full-length anti-CTLA-4 antibody inside the tumour. Its furthest stage is phase 1, for metastatic non-small cell lung cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1 Delivir trial NCT05788926 in metastatic NSCLC was terminated ('Sponsor decision not related to safety', registry updated July 2025). Transgene's site still lists TG6050 in its pipeline menu; no source read says it is discontinued. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Transgene: transgene.com","url":"https://www.transgene.com/tg6050/"},{"label":"Transgene: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT05788926"},{"label":"ClinicalTrials.gov: trials of TG6050","url":"https://clinicaltrials.gov/search?intr=TG6050"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":["ctla4"],"drugs":[],"companies":["transgene"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05788926"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"TG6050","modality":"Oncolytic virus (vaccinia, Invir.IO platform), intravenous","mechanism":"An oncolytic virus engineered to make human IL-12 and a full-length anti-CTLA-4 antibody inside the tumour.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/tg6050/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"target":[{"id":"ctla4","kind":"target","name":"CTLA-4","route":"/targets/ctla4/"}],"company":[{"id":"transgene","kind":"company","name":"Transgene","route":"/companies/transgene/"}],"trial":[{"id":"nct05788926","kind":"trial","name":"A Clinical Trial of TG6050 in Patients With Metastatic Non-Small Cell Lung Cancer (Delivir)","route":"/trials/nct05788926/"}]}}