{"entity":{"id":"tgfa","kind":"target","name":"TGFA","aka":["transforming growth factor alpha","Protransforming growth factor alpha"],"tldr":"TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.","summary":"TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.76, animal model 0.69, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11765","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11765"},{"label":"UniProt P01135","url":"https://www.uniprot.org/uniprotkb/P01135/entry"},{"label":"NCBI Gene 7039","url":"https://www.ncbi.nlm.nih.gov/gene/7039"},{"label":"Ensembl ENSG00000163235","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163235"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["renal-cell-carcinoma-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TGFA","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11765","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11765","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P01135","url":"https://www.uniprot.org/uniprotkb/P01135/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TGFA","url":"https://civicdb.org/features/5742","note":"1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000163235","url":"https://platform.opentargets.org/target/ENSG00000163235/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11765","ensembl":"ENSG00000163235","uniprot":"P01135","entrez":"7039","biology":"TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 2p13.3 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tgfa/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"pathway":[{"id":"renal-cell-carcinoma-signalling","kind":"pathway","name":"Renal cell carcinoma (KEGG map)","route":"/pathways/renal-cell-carcinoma-signalling/"}]}}