{"entity":{"id":"tgif1","kind":"target","name":"TGIF1","aka":["TGFB induced factor homeobox 1","Homeobox protein TGIF1","HPE4"],"tldr":"TGIF1 (Homeobox protein TGIF1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11776"},{"label":"UniProt Q15583","url":"https://www.uniprot.org/uniprotkb/Q15583/entry"},{"label":"NCBI Gene 7050","url":"https://www.ncbi.nlm.nih.gov/gene/7050"},{"label":"Ensembl ENSG00000177426","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177426"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TGIF1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11776","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15583","url":"https://www.uniprot.org/uniprotkb/Q15583/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TGIF1","url":"https://www.intogen.org/search?gene=TGIF1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11776","ensembl":"ENSG00000177426","uniprot":"Q15583","entrez":"7050","biology":"Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signalling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Location: Nucleus (UniProt). Locus 18p11.31 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tgif1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}