{"entity":{"id":"the-0504","kind":"drug","name":"THE-0504","aka":[],"tldr":"THE-0504 is an experimental human ferritin nanocage drug carrier loaded with a topoisomerase I inhibitor from Thena Biotech, in phase 1 trials for small cell lung cancer, colorectal carcinoma and pancreatic adenocarcinoma and other cancers.","summary":"THE-0504 is a human ferritin (HFt) nanocage drug carrier loaded with a topoisomerase I inhibitor from Thena Biotech. A human ferritin cage, activated by tumour proteases, that carries the topoisomerase I inhibitor Genz-644282 into cells with the CD71 receptor, aiming to avoid the toxicity of other CD71-targeted drugs. Its furthest stage is phase 1, for small cell lung cancer, colorectal carcinoma, pancreatic adenocarcinoma and gastric cancer. ClinicalTrials.gov registers it in one study linked below. Single-centre phase 1 NANOFER-THE-0504 NCT07646106 recruiting. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Thena Biotech: thenabiotech.com","url":"https://thenabiotech.com/"},{"label":"Thena Biotech: ebi.ac.uk","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC7877078&resultType=core&format=json"},{"label":"Thena Biotech: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07646106"},{"label":"ClinicalTrials.gov: trials of THE-0504","url":"https://clinicaltrials.gov/search?intr=THE-0504"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["sclc","colorectal","pancreatic","gastric","tnbc"],"sections":[],"technologies":[],"targets":["tfrc"],"drugs":[],"companies":["thena-biotech"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07646106"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"THE-0504","modality":"Human ferritin (HFt) nanocage drug carrier loaded with a topoisomerase I inhibitor","mechanism":"A human ferritin cage, activated by tumour proteases, that carries the topoisomerase I inhibitor Genz-644282 into cells with the CD71 receptor, aiming to avoid the toxicity of other CD71-targeted drugs.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/the-0504/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"target":[{"id":"tfrc","kind":"target","name":"TFRC","route":"/targets/tfrc/"}],"company":[{"id":"thena-biotech","kind":"company","name":"Thena Biotech","route":"/companies/thena-biotech/"}],"trial":[{"id":"nct07646106","kind":"trial","name":"THE-0504 in Patients With Solid Tumors","route":"/trials/nct07646106/"}]}}