{"entity":{"id":"thra","kind":"target","name":"THRA","aka":["thyroid hormone receptor alpha","Thyroid hormone receptor alpha","EAR-7.1/EAR-7.2","THRA3","AR7","NR1A1","TRalpha","TRalpha1","TRalpha2","c-ERBA-1","c-erbA","THRalpha","THRalpha1","THRalpha2","THRA1","THRA2","ERBA1"],"tldr":"THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.","summary":"Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.55, genetic association 0.00, clinical 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11796"},{"label":"UniProt P10827","url":"https://www.uniprot.org/uniprotkb/P10827/entry"},{"label":"NCBI Gene 7067","url":"https://www.ncbi.nlm.nih.gov/gene/7067"},{"label":"Ensembl ENSG00000126351","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126351"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"THRA","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11796","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10827","url":"https://www.uniprot.org/uniprotkb/P10827/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126351","url":"https://platform.opentargets.org/target/ENSG00000126351/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: thyroid cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:11796","ensembl":"ENSG00000126351","uniprot":"P10827","entrez":"7067","biology":"Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Location: Nucleus; Cytoplasm (UniProt). Locus 17q21.1 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.57 with thyroid cancer (MONDO_0002108)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/thra/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}