{"entity":{"id":"thunder-overc","kind":"trial","name":"THUNDER (blinded validation of Burning Rock's methylation test)","aka":["THUNDER","The Unintrusive Detection of EaRly-stage Cancers"],"tldr":"The Chinese validation study behind Burning Rock's OverC multi-cancer blood test, published in Annals of Oncology in 2023.","summary":"THUNDER (NCT04820868) is an observational study sponsored by Shanghai Zhongshan Hospital with Guangzhou Burning Rock Dx Co., Ltd. It validated the cell-free DNA methylation model for early cancer detection, with blood RNA markers also evaluated.\n\nThe registry record, read on 29 October 2026, gives its status as completed, with 2,508 participants enrolled, a start on 23 April 2021 and primary completion on 30 November 2021.","status":"completed","asOf":"2026-10-29","links":[{"label":"ClinicalTrials.gov NCT04820868","url":"https://clinicaltrials.gov/study/NCT04820868"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","liquid-biopsy"],"targets":[],"drugs":["overc-mcdbt"],"companies":["burning-rock"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-gao-thunder-ann-oncol-2023"],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04820868","phase":"observational","setting":"People with cancer and people without cancer in China, in a blinded prospective validation of a cell-free DNA methylation model","sponsor":"Shanghai Zhongshan Hospital with Guangzhou Burning Rock Dx Co., Ltd.","started":"2021-04-23","startedType":"actual","yearReported":2023,"enrolled":2508,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/thunder-overc/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"overc-mcdbt","kind":"drug","name":"OverC Multi-Cancer Detection Blood Test","route":"/drugs/overc-mcdbt/"}],"company":[{"id":"burning-rock","kind":"company","name":"Burning Rock Biotech","route":"/companies/burning-rock/"}],"paper":[{"id":"paper-gao-thunder-ann-oncol-2023","kind":"paper","name":"Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies","route":"/key-papers/paper-gao-thunder-ann-oncol-2023/"}]}}