{"entity":{"id":"tie2","kind":"target","name":"TIE2 receptor (TEK)","aka":[],"tldr":"TIE2 is the angiopoietin receptor that keeps blood vessels stable; regorafenib and cabozantinib block it as part of their attack on the tumour's blood supply.","summary":"TEK (TIE2) is the receptor for angiopoietins 1 and 2 on endothelial cells and a subset of macrophages, controlling vessel maturation and remodelling. Regorafenib and cabozantinib inhibit TIE2 alongside VEGF receptors, and the angiopoietin-2 antibody trebananib was tested in ovarian cancer without approval. TIE2-expressing macrophages are a source of resistance to anti-VEGF therapy.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/TEK_tyrosine_kinase","links":[{"label":"UniProt Q02763: TEK","url":"https://www.uniprot.org/uniprotkb/Q02763/entry"},{"label":"HGNC:11724 TEK","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11724"},{"label":"ChEMBL target CHEMBL4128","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL4128"}],"tags":[],"related":["vegf"],"cancers":["colorectal","hcc","rcc"],"sections":[],"technologies":[],"targets":[],"drugs":["regorafenib","cabozantinib"],"companies":[],"institutions":[],"pathways":[],"terms":["angiogenesis"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"TEK","biology":"A receptor tyrosine kinase activated by angiopoietin-1 and antagonised or weakly activated by angiopoietin-2, signalling through AKT to stabilise the endothelium.","whereFound":["Tumour and normal endothelium","TIE2-expressing monocytes and macrophages"],"targetClass":"kinase","prevalence":[]},"route":"/targets/tie2/","neighbours":{"target":[{"id":"vegf","kind":"target","name":"VEGF / VEGFR","route":"/targets/vegf/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"drug":[{"id":"cabozantinib","kind":"drug","name":"Cabozantinib","route":"/drugs/cabozantinib/"},{"id":"regorafenib","kind":"drug","name":"Regorafenib","route":"/drugs/regorafenib/"}],"term":[{"id":"angiogenesis","kind":"term","name":"Angiogenesis","route":"/terms/angiogenesis/"}]}}