{"entity":{"id":"tiger-trial","kind":"trial","name":"TIGER: standard-dose TIP versus high-dose TI-CE with stem cell transplant as first salvage for relapsed germ cell tumours","aka":[],"tldr":"The trial meant to settle a thirty-year argument: whether men whose germ cell tumour comes back after cisplatin should get standard salvage chemotherapy or high-dose chemotherapy with a stem cell transplant.","summary":"Relapsed germ cell tumours are still curable, but retrospective comparisons have long suggested that high-dose chemotherapy with stem cell rescue beats conventional-dose salvage, without a randomised proof. TIGER, run by the Alliance with European cooperative groups, randomises patients at first relapse between four cycles of TIP and the TI-CE high-dose programme. It is active and no longer recruiting, with overall survival as the primary endpoint. Patients with primary mediastinal non-seminoma, the poorest-risk extragonadal group, are among those most in need of the answer.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT02375204","url":"https://clinicaltrials.gov/study/NCT02375204"}],"tags":["owner-request"],"related":[],"cancers":["testicular","extragonadal-germ-cell-tumour"],"sections":[],"technologies":["autologous-stem-cell-transplant"],"targets":[],"drugs":["paclitaxel","ifosfamide","cisplatin","carboplatin","etoposide"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT02375204","phase":"3","setting":"First relapse of metastatic germ cell tumour after cisplatin-based chemotherapy, including extragonadal primaries: conventional-dose paclitaxel, ifosfamide and cisplatin (TIP) versus high-dose carboplatin and etoposide with autologous stem cell support after paclitaxel and ifosfamide (TI-CE); international, 420 planned, started 2015","sponsor":"Alliance for Clinical Trials in Oncology","enrolled":420,"outcomes":[]},"route":"/trials/tiger-trial/","neighbours":{"cancer":[{"id":"extragonadal-germ-cell-tumour","kind":"cancer","name":"Extragonadal germ cell tumour","route":"/cancers/extragonadal-germ-cell-tumour/"},{"id":"testicular","kind":"cancer","name":"Testicular germ cell tumours","route":"/cancers/testicular/"}],"technology":[{"id":"autologous-stem-cell-transplant","kind":"technology","name":"Autologous stem cell transplant (high-dose therapy)","route":"/technologies/autologous-stem-cell-transplant/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"ifosfamide","kind":"drug","name":"Ifosfamide","route":"/drugs/ifosfamide/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"}]}}