{"entity":{"id":"tim3-blockade","kind":"technology","name":"TIM-3 blockade","aka":[],"tldr":"Antibodies against TIM-3, a checkpoint on exhausted T cells and myeloid cells, tested mostly with PD-1 drugs and in blood cancers.","summary":"T-cell immunoglobulin and mucin domain 3 (TIM-3, gene HAVCR2) marks the most exhausted T cells and is also expressed on leukaemic stem cells and myeloid cells. Antibodies such as sabatolimab and cobolimab have been tested with PD-1 blockade in solid tumours and with hypomethylating agents in myelodysplastic syndromes and acute myeloid leukaemia; the STIMULUS programme in MDS did not meet its endpoints, and development is concentrated in combination settings.","status":"phase-2","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/HAVCR2","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/HAVCR2"}],"tags":[],"related":[],"cancers":["mds","aml","nsclc"],"sections":["immunotherapy"],"technologies":[],"targets":["tim3"],"drugs":["cobolimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"principle":"Antibodies block TIM-3 binding to galectin-9, phosphatidylserine and CEACAM1, restoring T-cell and innate immune function.","strengths":["Targets both adaptive and innate immune brakes","Expressed on leukaemic stem cells"],"limitations":["Phase 3 MDS trials negative","Solid tumour activity modest so far"]},"route":"/technologies/tim3-blockade/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"target":[{"id":"tim3","kind":"target","name":"TIM-3","route":"/targets/tim3/"}],"drug":[{"id":"cobolimab","kind":"drug","name":"Cobolimab","route":"/drugs/cobolimab/"}]}}