{"entity":{"id":"tln-121","kind":"drug","name":"TLN-121","aka":[],"tldr":"TLN-121 is an experimental protein degrader from Treeline Biosciences, in phase 1 trials for B-cell lymphoma, T-cell lymphoma and non-Hodgkin lymphoma.","summary":"TLN-121 is a protein degrader (small molecule) from Treeline Biosciences. Designed to remove the protein BCL6, which some lymphoma cells use to switch off genes, while avoiding off-target effects. Its furthest stage is phase 1, for B-cell lymphoma, T-cell lymphoma and non-Hodgkin lymphoma. ClinicalTrials.gov registers it in one study linked below. Registry NCT07082803 phase 1 recruiting, alone and with zeprumetostat (TLN-254). Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Treeline Biosciences: treeline.bio","url":"https://treeline.bio/medicines"},{"label":"Treeline Biosciences: treeline.bio","url":"https://treeline.bio/medicines"},{"label":"ClinicalTrials.gov: trials of TLN-121","url":"https://clinicaltrials.gov/search?intr=TLN-121"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":["bcl6"],"drugs":[],"companies":["treeline-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07082803"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"TLN-121","modality":"Protein degrader (small molecule)","mechanism":"Designed to remove the protein BCL6, which some lymphoma cells use to switch off genes, while avoiding off-target effects.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/tln-121/","neighbours":{"cancer":[{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}],"target":[{"id":"bcl6","kind":"target","name":"BCL6","route":"/targets/bcl6/"}],"company":[{"id":"treeline-biosciences","kind":"company","name":"Treeline Biosciences","route":"/companies/treeline-biosciences/"}],"trial":[{"id":"nct07082803","kind":"trial","name":"TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas","route":"/trials/nct07082803/"}]}}