{"entity":{"id":"tln-372","kind":"drug","name":"TLN-372","aka":[],"tldr":"TLN-372 is an experimental small molecule pan-KRAS inhibitor from Treeline Biosciences, in phase 1 trials for KRAS-mutant solid tumours.","summary":"TLN-372 is a small molecule pan-KRAS inhibitor from Treeline Biosciences. Designed to achieve deep and sustained inhibition of KRAS across its mutant forms (pan-KRAS), not only G12C. Its furthest stage is phase 1, for KRAS-mutant solid tumours. ClinicalTrials.gov registers it in one study linked below. Registry NCT07204340 phase 1 recruiting, alone and with cetuximab or pembrolizumab. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Treeline Biosciences: treeline.bio","url":"https://treeline.bio/medicines"},{"label":"Treeline Biosciences: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07204340"},{"label":"ClinicalTrials.gov: trials of TLN-372","url":"https://clinicaltrials.gov/search?intr=TLN-372"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["kras"],"drugs":[],"companies":["treeline-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07204340"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"TLN-372","modality":"Small molecule pan-KRAS inhibitor","mechanism":"Designed to achieve deep and sustained inhibition of KRAS across its mutant forms (pan-KRAS), not only G12C.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/tln-372/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"kras","kind":"target","name":"KRAS","route":"/targets/kras/"}],"company":[{"id":"treeline-biosciences","kind":"company","name":"Treeline Biosciences","route":"/companies/treeline-biosciences/"}],"trial":[{"id":"nct07204340","kind":"trial","name":"TLN-372 in Advanced KRAS Mutant Solid Tumors","route":"/trials/nct07204340/"}]}}