{"entity":{"id":"tln1","kind":"target","name":"TLN1","aka":["talin 1","Talin-1","ILWEQ"],"tldr":"TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11845","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11845"},{"label":"UniProt Q9Y490","url":"https://www.uniprot.org/uniprotkb/Q9Y490/entry"},{"label":"NCBI Gene 7094","url":"https://www.ncbi.nlm.nih.gov/gene/7094"},{"label":"Ensembl ENSG00000137076","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137076"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TLN1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11845","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11845","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y490","url":"https://www.uniprot.org/uniprotkb/Q9Y490/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137076","url":"https://platform.opentargets.org/target/ENSG00000137076/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11845","ensembl":"ENSG00000137076","uniprot":"Q9Y490","entrez":"7094","biology":"High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. Location: Cell projection, ruffle membrane; Cytoplasm, cytoskeleton; Cell surface; Cell junction, focal adhesion (UniProt). Locus 9p13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/tln1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}