{"entity":{"id":"tlr7","kind":"target","name":"Toll-like receptor 7 (TLR7)","aka":[],"tldr":"TLR7 is an innate immune sensor for viral RNA; the cream imiquimod switches it on to make the skin's immune cells attack superficial basal cell carcinoma.","summary":"Toll-like receptor 7 sits in the endosomes of plasmacytoid dendritic cells and other immune cells and recognises single-stranded RNA. Imiquimod is a synthetic TLR7 agonist applied as a cream: it triggers interferon-alpha and other cytokines locally, recruiting an immune response that clears superficial basal cell carcinoma, actinic keratoses and genital warts. TLR7 and TLR8 agonists are also being tested as injectable immune adjuvants in solid tumours.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/TLR7","links":[{"label":"UniProt Q9NYK1: TLR7","url":"https://www.uniprot.org/uniprotkb/Q9NYK1/entry"},{"label":"HGNC:15631 TLR7","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15631"},{"label":"ChEMBL target CHEMBL5936","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5936"}],"tags":[],"related":[],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["imiquimod"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"TLR7","biology":"An endosomal pattern-recognition receptor signalling through MyD88 to NF-kB and IRF7, driving type I interferon production.","whereFound":["Plasmacytoid dendritic cells and B cells","Skin immune cells activated by topical imiquimod"],"targetClass":"other","prevalence":[]},"route":"/targets/tlr7/","neighbours":{"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"}],"drug":[{"id":"imiquimod","kind":"drug","name":"Imiquimod","route":"/drugs/imiquimod/"}]}}