{"entity":{"id":"tlx1","kind":"target","name":"TLX1","aka":["T cell leukemia homeobox 1","T-cell leukemia homeobox protein 1","TCL3","HOX11"],"tldr":"TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.84, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5056","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5056"},{"label":"UniProt P31314","url":"https://www.uniprot.org/uniprotkb/P31314/entry"},{"label":"NCBI Gene 3195","url":"https://www.ncbi.nlm.nih.gov/gene/3195"},{"label":"Ensembl ENSG00000107807","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107807"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TLX1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5056","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5056","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31314","url":"https://www.uniprot.org/uniprotkb/P31314/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000107807","url":"https://platform.opentargets.org/target/ENSG00000107807/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5056","ensembl":"ENSG00000107807","uniprot":"P31314","entrez":"3195","biology":"Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Location: Nucleus (UniProt). Locus 10q24.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/tlx1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}