{"entity":{"id":"tmem127","kind":"target","name":"TMEM127","aka":["transmembrane protein 127","Transmembrane protein 127","FLJ20507","FLJ22257"],"tldr":"TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.","summary":"Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.19, genetic association 0.59, somatic mutation 0.93, animal model 0.47).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:26038","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26038"},{"label":"UniProt O75204","url":"https://www.uniprot.org/uniprotkb/O75204/entry"},{"label":"NCBI Gene 55654","url":"https://www.ncbi.nlm.nih.gov/gene/55654"},{"label":"Ensembl ENSG00000135956","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135956"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TMEM127","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:26038","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26038","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75204","url":"https://www.uniprot.org/uniprotkb/O75204/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000135956","url":"https://platform.opentargets.org/target/ENSG00000135956/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: melanoma 0.51, neuroendocrine neoplasm 0.78 (GraphQL API, CC0)"}],"hgnc":"HGNC:26038","ensembl":"ENSG00000135956","uniprot":"O75204","entrez":"55654","biology":"Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor. Location: Cell membrane; Cytoplasm (UniProt). Locus 2q11.2 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.78 with neuroendocrine neoplasm (MONDO_0019496)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/tmem127/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}