{"entity":{"id":"tmem238l","kind":"target","name":"TMEM238L","aka":["transmembrane protein 238 like","Transmembrane protein 238-like","FORCP","LINC00675"],"tldr":"TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:44356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:44356"},{"label":"UniProt A6NJY4","url":"https://www.uniprot.org/uniprotkb/A6NJY4/entry"},{"label":"NCBI Gene 100289255","url":"https://www.ncbi.nlm.nih.gov/gene/100289255"},{"label":"Ensembl ENSG00000263429","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000263429"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TMEM238L","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:44356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:44356","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A6NJY4","url":"https://www.uniprot.org/uniprotkb/A6NJY4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000263429","url":"https://platform.opentargets.org/target/ENSG00000263429/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:44356","ensembl":"ENSG00000263429","uniprot":"A6NJY4","entrez":"100289255","biology":"May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt). Locus 17p13.1-p12 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)"],"targetClass":"other","prevalence":[]},"route":"/targets/tmem238l/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}