{"entity":{"id":"tnfrsf10b","kind":"target","name":"TNFRSF10B","aka":["TNF receptor superfamily member 10b","Tumor necrosis factor receptor superfamily member 10B","DR5","KILLER","TRICK2A","TRAIL-R2","TRICKB","CD262","TRAILR2"],"tldr":"TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, clinical 0.20, literature 0.98, genetic association 0.79, animal model 0.27).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11905","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11905"},{"label":"UniProt O14763","url":"https://www.uniprot.org/uniprotkb/O14763/entry"},{"label":"NCBI Gene 8795","url":"https://www.ncbi.nlm.nih.gov/gene/8795"},{"label":"Ensembl ENSG00000120889","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120889"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["extrinsic-apoptosis-death-receptors"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.20. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TNFRSF10B","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11905","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11905","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14763","url":"https://www.uniprot.org/uniprotkb/O14763/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000120889","url":"https://platform.opentargets.org/target/ENSG00000120889/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11905","ensembl":"ENSG00000120889","uniprot":"O14763","entrez":"8795","biology":"Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Location: Membrane (UniProt). Locus 8p21.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/tnfrsf10b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"extrinsic-apoptosis-death-receptors","kind":"pathway","name":"Extrinsic apoptosis (death receptors)","route":"/pathways/extrinsic-apoptosis-death-receptors/"}]}}