{"entity":{"id":"tnfrsf13b","kind":"target","name":"TNFRSF13B","aka":["TNF receptor superfamily member 13B","Tumor necrosis factor receptor superfamily member 13B","CD267","IGAD2"],"tldr":"TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.","summary":"Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.93, animal model 0.48, genetic association 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18153","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18153"},{"label":"UniProt O14836","url":"https://www.uniprot.org/uniprotkb/O14836/entry"},{"label":"NCBI Gene 23495","url":"https://www.ncbi.nlm.nih.gov/gene/23495"},{"label":"Ensembl ENSG00000240505","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000240505"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TNFRSF13B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18153","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18153","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14836","url":"https://www.uniprot.org/uniprotkb/O14836/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000240505","url":"https://platform.opentargets.org/target/ENSG00000240505/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: plasma cell myeloma 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:18153","ensembl":"ENSG00000240505","uniprot":"O14836","entrez":"23495","biology":"Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Location: Membrane (UniProt). Locus 17p11.2 (HGNC).","whereFound":["Multiple myeloma: Open Targets association 0.56 with plasma cell myeloma (MONDO_0009693)"],"targetClass":"other","prevalence":[]},"route":"/targets/tnfrsf13b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}]}}