{"entity":{"id":"tnfrsf18","kind":"target","name":"GITR (TNFRSF18)","aka":["GITR","AITR","CD357","TNF receptor superfamily member 18"],"tldr":"GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety.","summary":"TNFRSF18 (chromosome 1p36.33) encodes GITR, the receptor for TNFSF18 (GITR ligand), which seems to be involved in interactions between activated T lymphocytes and endothelial cells and in the regulation of T-cell-receptor-mediated cell death, and mediates NF-kappa-B activation through the TRAF2/NIK pathway; it is expressed in lymph node and peripheral blood leukocytes and weakly in spleen (UniProt Q9Y5U5). BMS-986156, a GITR agonist, completed phase 1/2 alone and with nivolumab (NCT02598960); TRX518 was discontinued for reasons unrelated to safety (NCT03861403).","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:11914","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11914"},{"label":"UniProt Q9Y5U5","url":"https://www.uniprot.org/uniprotkb/Q9Y5U5/entry"},{"label":"NCBI Gene 8784","url":"https://www.ncbi.nlm.nih.gov/gene/8784"},{"label":"ClinicalTrials.gov NCT02598960","url":"https://clinicaltrials.gov/study/NCT02598960"}],"tags":["checkpoint-map"],"related":["tnfrsf4","cd137","nivolumab"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-immunity-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"TNFRSF18","role":["immune-checkpoint"],"sources":[{"label":"HGNC HGNC:11914","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11914","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt Q9Y5U5","url":"https://www.uniprot.org/uniprotkb/Q9Y5U5/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:11914","ensembl":"ENSG00000186891","uniprot":"Q9Y5U5","entrez":"8784","biology":"A TNF-receptor-superfamily costimulator on activated and regulatory T cells.","whereFound":["Lymph node and peripheral blood leukocytes (UniProt Q9Y5U5)"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/tnfrsf18/","neighbours":{"target":[{"id":"cd137","kind":"target","name":"CD137 (4-1BB, TNFRSF9)","route":"/targets/cd137/"},{"id":"tnfrsf4","kind":"target","name":"OX40 (TNFRSF4)","route":"/targets/tnfrsf4/"}],"drug":[{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"}],"pathway":[{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"}]}}