{"entity":{"id":"tnfsf10","kind":"target","name":"TNFSF10","aka":["TNF superfamily member 10","Tumor necrosis factor ligand superfamily member 10","TRAIL","Apo-2L","TL2","CD253","TANCR"],"tldr":"TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.25, genetic association 0.62).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11925","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11925"},{"label":"UniProt P50591","url":"https://www.uniprot.org/uniprotkb/P50591/entry"},{"label":"NCBI Gene 8743","url":"https://www.ncbi.nlm.nih.gov/gene/8743"},{"label":"Ensembl ENSG00000121858","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121858"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["extrinsic-apoptosis-death-receptors"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TNFSF10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11925","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11925","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P50591","url":"https://www.uniprot.org/uniprotkb/P50591/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000121858","url":"https://platform.opentargets.org/target/ENSG00000121858/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11925","ensembl":"ENSG00000121858","uniprot":"P50591","entrez":"8743","biology":"Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Location: Cell membrane; Secreted (UniProt). Locus 3q26.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/tnfsf10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"extrinsic-apoptosis-death-receptors","kind":"pathway","name":"Extrinsic apoptosis (death receptors)","route":"/pathways/extrinsic-apoptosis-death-receptors/"}]}}