{"entity":{"id":"tns1","kind":"target","name":"TNS1","aka":["tensin 1","Tensin-1","DKFZp586K0617","PPP1R155","MXRA6"],"tldr":"TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, animal model 0.39, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11973","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11973"},{"label":"UniProt Q9HBL0","url":"https://www.uniprot.org/uniprotkb/Q9HBL0/entry"},{"label":"NCBI Gene 7145","url":"https://www.ncbi.nlm.nih.gov/gene/7145"},{"label":"Ensembl ENSG00000079308","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079308"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TNS1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11973","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11973","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HBL0","url":"https://www.uniprot.org/uniprotkb/Q9HBL0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000079308","url":"https://platform.opentargets.org/target/ENSG00000079308/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11973","ensembl":"ENSG00000079308","uniprot":"Q9HBL0","entrez":"7145","biology":"May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarisation and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. Location: Cell surface; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 2q35 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tns1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}