{"entity":{"id":"tns3","kind":"target","name":"TNS3","aka":["tensin 3","Tensin-3","TEM6","H_NH0549I23.2","FLJ13732","TENS1"],"tldr":"TNS3 (Tensin-3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Basal cell carcinoma.","summary":"May act as a protein phosphatase and/or a lipid phosphatase. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.80, animal model 0.31, genetic association 0.72).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21616","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21616"},{"label":"UniProt Q68CZ2","url":"https://www.uniprot.org/uniprotkb/Q68CZ2/entry"},{"label":"NCBI Gene 64759","url":"https://www.ncbi.nlm.nih.gov/gene/64759"},{"label":"Ensembl ENSG00000136205","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136205"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TNS3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21616","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21616","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q68CZ2","url":"https://www.uniprot.org/uniprotkb/Q68CZ2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136205","url":"https://platform.opentargets.org/target/ENSG00000136205/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.52, basal cell carcinoma 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:21616","ensembl":"ENSG00000136205","uniprot":"Q68CZ2","entrez":"64759","biology":"May act as a protein phosphatase and/or a lipid phosphatase. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organisation. Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Location: Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7p12.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)","Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tns3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}