{"entity":{"id":"top2b","kind":"target","name":"TOP2B","aka":["DNA topoisomerase II beta","DNA topoisomerase 2-beta","top2beta","TOPIIB"],"tldr":"TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.","summary":"Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.93, animal model 0.39, genetic association 0.45, clinical 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11990","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11990"},{"label":"UniProt Q02880","url":"https://www.uniprot.org/uniprotkb/Q02880/entry"},{"label":"NCBI Gene 7155","url":"https://www.ncbi.nlm.nih.gov/gene/7155"},{"label":"Ensembl ENSG00000077097","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000077097"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer","neuroendocrine","breast-cancer","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TOP2B","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11990","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11990","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q02880","url":"https://www.uniprot.org/uniprotkb/Q02880/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000077097","url":"https://platform.opentargets.org/target/ENSG00000077097/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: small cell lung carcinoma 0.56, neuroendocrine neoplasm 0.57, breast cancer 0.55, lung cancer 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:11990","ensembl":"ENSG00000077097","uniprot":"Q02880","entrez":"7155","biology":"Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. Location: Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus (UniProt). Locus 3p24.2 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.58 with lung cancer (MONDO_0008903)","Neuroendocrine tumours: Open Targets association 0.57 with neuroendocrine neoplasm (MONDO_0019496)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Small-cell lung cancer: Open Targets association 0.56 with small cell lung carcinoma (MONDO_0008433)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/top2b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}]}}